Chronic pruritus (CP) is defined by the presence of the sensation for at least 6 weeks according to the International Forum for the Study of Itch (IFSI). CP is described as a symptom of pruritogenic diseases such as inflammatory, infectious and autoimmune dermatoses, hepatobiliary and chronic kidney diseases, systemic and cutaneous lymphoma, solid neoplasms, neuropathic and psychic diseases. As a disease symptom, CP is highly prevalent in the population. Though CP parallels the onset of the causing disease, treatment of the underlying disease does not control, in most cases, the pruritus. In diabetes mellitus, for example, control of the metabolic situation does not lead to a relief of pruritus. In atopic dermatitis, itching and scratching can persist independent of the clinical healing of eczema and can trigger recurrence of the disease.
The neurobiology of CP seems to be unique and independent from the causing disease. CP thus necessitates specific and own therapy approaches independent of the triggering initial condition. In fact, recent several studies confirmed the assumption of a peripheral and central neuronal sensitization underlying CP. This Research Topic shall summarize our improved understanding of the neurobiology of pruritus, the identification of novel pharmaceutical targets and methods in itch research.
The aim of this Research Topic is to gather manuscripts on the neurobiology and the clinical therapy of CP, with specific emphasis on, but not limited to, the following questions and themes.
• Which nerves transmit itch?
• Neuronal sensitization to itch: what is new?
• Central representation of itch: what is our current understanding?
• The connection between itch and genes.
• Electrical stimulation in humans
• Mast cells: still important in the itch field?
• Which interleukins are important in dermatological itch?
• Molecular mediators in cholestatic pruritus: what is new?
• Itch: a global problem?
• Teledermatology for itching
• Should we use pain assessment instruments (QST) in itch?
• Small fiber neuropathy: link to itch?
• Neuropathic itch: routes to clinical diagnostic
• Psychic factors in itch and pain: similarities?
• Management of Drug-induced pruritus.
• Chronic Prurigo
• Immunological treatment of itch
• Uremic pruritus: drugs in the pipeline
• Atopic Itch: what is new?
• Itch in scabies: what do we know?
A standard EDITORIAL TRACKING SYSTEM is utilized for manuscript submission, review, editorial processing and tracking which can be securely accessed by the authors, reviewers and editors for monitoring and tracking the article processing. Manuscripts can be uploaded online at Editorial Tracking System (https://www.longdom.org/submissions/clinical-experimental-dermatology-research.html) or forwarded to the Editorial Office at firstname.lastname@example.org
Journal of Clinical & Experimental Dermatology Research